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J Clin Virol. 2005 Jun;33(2):158-67.

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Simultaneous type 1 diabetes onset in mother and son coincident with an enteroviral infection.

Maria H, Elshebani A, Anders O, Torsten T, Gun F.

Microbiology and Tumor Biology Center,  Stockholm, Sweden.

Enterovirus (EV) infections have been implicated in the development of type 1 diabetes. . They may cause beta-cell destruction either by cytolytic infection of the cells or indirectly by triggering the autoimmune response. Virus was isolated from a woman at diagnosis of  and in addition, virus was isolated from her son at diagnosis of  at the same day . None of the isolates could initially be serotyped by conventional methods. The was genotyped and after sub-cultivation it was also serotyped as Coxsackievirus B5. The mother revealed antibodies against GAD65. The boy and the father both revealed a significant increase in neutralization antibody titre against two strains of CBV-4, clearly indicating a recent or ongoing EV infection. In addition, the brother showed such a titre rise against another CBV-4 strain (E2) and against a CBV-5 strain (4429). These results show that the whole family had a proven EV infection at the time of T1D diagnosis of the mother and the 10-years-old boy, indicating that the infection might cause or accelerate the T1D.

PMID: 15911432 [PubMed - in process]

 

J Med Virol. 2005 Jul;76(3):373-7.

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Islet cell related antibodies and type 1 diabetes associated with echovirus 30 epidemic: A case report.

Cabrera-Rode E,

Department of Immunology of Diabetes, N,IE Havana, Cuba.

Type 1 diabetes associated genes account for less than 50% of disease susceptibility. Human enteroviruses have been implicated as environmental factors that might trigger and/or accelerate this autoimmune disorder. We now report of a 12-year-old girl that developed pancreatic autoimmunity and type 1 diabetes after enteroviral infection. Diabetes-associated autoimmunity was evaluated by measurement of several islet cell related autoantibodies. Neutralizing antibodies to different enteroviruses were determined in the case and eight children suffering from aseptic meningitis during a large scale epidemic. Several types of diabetes-associated antibodies were detected post-infection in the adolescent with newly diagnosed type 1 diabetes, including islet cell antibodies (ICA) and tyrosine phosphatase antibodies (IA2A). ICA but not IA2A appeared in the non-diabetic enterovirus-infected subjects. Based on virological studies, type 1 diabetes pathogenesis process could have been triggered by echovirus 30 infections. This study provides the first evidence of an association between echovirus 30 infection with the presence of pancreatic autoimmunity and type 1 diabetes. Our data suggest that echovirus 30 Cuban strain could be considered a potentially diabetogenic enteroviral variant. J. Med. Virol. 76:373-377, 2005. (c) 2005 Wiley-Liss, Inc.

PMID: 15902705 [PubMed - in process]

 

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